The role of benfotiamine in drug patients: تفاوت میان نسخه‌ها

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<ref>[https://pubmed.ncbi.nlm.nih.gov/15726875 Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study) ]</ref>  
<ref>[https://pubmed.ncbi.nlm.nih.gov/15726875 Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study) ]</ref>  


Benfotiamine has direct antioxidant properties as well<ref>[https://pubmed.ncbi.nlm.nih.gov/18384109 Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro ]</ref>.  
Benfotiamine has direct antioxidant properties as well<ref>[https://pubmed.ncbi.nlm.nih.gov/18384109 Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro ]</ref>.  


It has been shown that treatment with benfotiamine avoids functional and structural changes in the retina. Benfotiamine has been demonstrated that benfotiamine protects against non-diabetic vascular damage<ref>[ https://pubmed.ncbi.nlm.nih.gov/20107192 Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway]</ref>  
It has been shown that treatment with benfotiamine avoids functional and structural changes in the retina. Benfotiamine has been demonstrated that benfotiamine protects against non-diabetic vascular damage<ref>[ https://pubmed.ncbi.nlm.nih.gov/20107192 Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway]</ref>  


In a recent study, benfotiamine was shown to prevent cardiac dysfunction in diabetes through modulating PI3 kinase‐AKT pathwayپ <ref>[https://pubmed.ncbi.nlm.nih.gov/20107192 Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway ]</ref>
In a recent study, benfotiamine was shown to prevent cardiac dysfunction in diabetes through modulating PI3 kinase‐AKT pathway <ref>[https://pubmed.ncbi.nlm.nih.gov/20107192 Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway ]</ref>


Therefore, by affecting oxidative stress, a common pathogenetic pathway, benfotiamine might potentially prevent multiple chronic diabetes problems <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015539/ Preventive effects of benfotiamine in chronic diabetic complications ]</ref>.
Therefore, by affecting oxidative stress, a common pathogenetic pathway, benfotiamine might potentially prevent multiple chronic diabetes problems <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015539/ Preventive effects of benfotiamine in chronic diabetic complications ]</ref>.

نسخهٔ کنونی تا ‏۳۰ اوت ۲۰۲۲، ساعت ۱۶:۲۶

What is Benfotamine?

What is Benfotiamine? Benfotiamine is a synthetic B1, and Benfotiamine is a fat-soluble vitamin B1. Vitamin B1 itself is naturally water-soluble. Vitamin B1 plays a role in the mitochondrial engine involved in glucose metabolism. The more glucose you have in your machine, the higher your blood sugar will be and the lower your vitamin B1 will be.

Dr. Berg's opinion about benfotiamine

This is one of the only synthetic vitamins I like because it has virtually no side effects. I believe every diabetic should take benfotiamine.

The effects of benfotiamine on diabetic patients

With diabetes, there are four main tissues involved, and B1 can help with all of them:

1. Nerves/brain - Neuropathy 2. Eyes - Retina 3. Kidney - Nephron 4. Heart vessels - Microvascular endothelial dysfunction

Benfotiamine:

• 3-5x more absorption

• Protects against oxidation and AGEs

• Decreases A1C

• Protection

When it comes to benfotiamine dosage, consider taking at least 600mg of benfotiamine per day, and you can spread it out. You should also be doing healthy keto and intermittent fasting.


Ketonia dietitian expert

Thiamine, as a water-soluble vitamin, plays a crucial purpose in the metabolism of energy, making it an essential component of the diet. The protective effects of thiamine against diabetic vascular problems have been well documented. However, delayed absorption and decreased bioavailability are major limiting factors for its clinical use. To overcome this issue, lipid-soluble thiamine derivatives (allithiamines) were developed. Among the many synthetic lipophilic products of thiamine, benfotiamine (BFT) is regarded as the first choice based on its safety and clinical efficacy studies[۱] .


High-dose benfotiamine (up to 600 mg/day) has been shown in short-term studies (3–12 weeks) to improve symptom scores in diabetic polyneuropathy[۲][۳] Benfotiamine blocks several hyperglycemia‐induced pathways of tissue damage in the retina and causes a reduction in superoxide production. [۴]

Benfotiamine has direct antioxidant properties as well[۵].

It has been shown that treatment with benfotiamine avoids functional and structural changes in the retina. Benfotiamine has been demonstrated that benfotiamine protects against non-diabetic vascular damage[۶]

In a recent study, benfotiamine was shown to prevent cardiac dysfunction in diabetes through modulating PI3 kinase‐AKT pathway [۷]

Therefore, by affecting oxidative stress, a common pathogenetic pathway, benfotiamine might potentially prevent multiple chronic diabetes problems [۸].


Ramin Taghizadeh M.C.NO:6769

Resources

  1. ↑ Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate
  2. ↑ Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study)
  3. ↑ [ https://pubmed.ncbi.nlm.nih.gov/18473286 Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study ]
  4. ↑ Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study)
  5. ↑ Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro
  6. ↑ [ https://pubmed.ncbi.nlm.nih.gov/20107192 Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway]
  7. ↑ Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway
  8. ↑ Preventive effects of benfotiamine in chronic diabetic complications
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